Retinoblastoma

A malignant tumor arising from the nuclear layer of the retina that is the most common primary tumor of the eye in children. The tumor tends to occur in early childhood or infancy and may be present at birth. The majority are sporadic, but the condition may be transmitted as an autosomal dominant trait. Histologic features include dense cellularity, small round polygonal cells, and areas of calcification and necrosis. An abnormal pupil reflex (leukokoria); NYSTAGMUS, PATHOLOGIC; STRABISMUS; and visual loss represent common clinical characteristics of this condition. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2104)

Also Known As:

Glioblastoma, Retinal; Glioma, Retinal; Neuroblastoma, Retinal; Eye Cancer, Retinoblastoma; Familial Retinoblastoma; Hereditary Retinoblastoma; Sporadic Retinoblastoma; Cancer, Retinoblastoma Eye; Cancers, Retinoblastoma Eye; Eye Cancers, Retinoblastoma; Familial Retinoblastomas; Glioblastomas, Retinal; Gliomas, Retinal; Hereditary Retinoblastomas; Neuroblastomas, Retinal; Retinal Glioblastoma; Retinal Glioblastomas; Retinal Glioma; Retinal Gliomas; Retinal Neuroblastoma; Retinal Neuroblastomas; Retinoblastoma Eye Cancer; Retinoblastoma Eye Cancers; Retinoblastoma, Familial; Retinoblastoma, Hereditary; Retinoblastoma, Sporadic; Retinoblastomas; Retinoblastomas, Familial; Retinoblastomas, Hereditary; Retinoblastomas, Sporadic; Sporadic Retinoblastomas

Neoplasms: 1324753
- Neoplasms by Site: 4
  - Eye Neoplasms: 61
    - Retinal Neoplasms: 135
      - Retinoblastoma: 7420
- Neoplasms by Histologic Type: 2
  - Germ Cell and Embryonal Neoplasms: 4454
    - Neuroectodermal Tumors: 217
      - Neuroepithelial Neoplasms: 412
        Retinoblastoma: 7420
  - Glandular and Epithelial Neoplasms: 439
    - Neuroepithelial Neoplasms: 412
      - Retinoblastoma: 7420
  - Nerve Tissue Neoplasms: 1
    - Neuroectodermal Tumors: 217
      - Neuroepithelial Neoplasms: 412
        Retinoblastoma: 7420
Eye Diseases: 3522
- Retinal Diseases: 3014
  - Retinal Neoplasms: 135
    - Retinoblastoma: 7420
- Eye Neoplasms: 61
  - Retinal Neoplasms: 135
    - Retinoblastoma: 7420
- Hereditary Eye Diseases: 18
  - Retinoblastoma: 7420

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Disease

Drug/Important Bio-Agent (IBA)